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This 36-aminoacid peptide and its receptors are widely distributed throughout the CNS of mammals, including humans. ICV NPY administration potently stimulates eating, which is likely to be due to the contribution of NPY receptors in numerous brain sites. The NPY neurones most relevant to eating are those in the ARC, projecting to the PVN, as described above (Figure 6.20). However, NPY also induces hyperphagia when injected into the LHA or the fourth ventricle (in the caudal brainstem). NPY also reduces energy expenditure by inhibiting the sympathetic innervation of thermogenic tissues. Importantly, repeated administration results in obesity (Beck, 2006; Billington et al., 1991; Stanley et al., 1993) and, conversely, chronic inhibition of ARC NPY neurones by local injection of antisense NPY mRNA decreases food intake and body weight Reference . Interestingly, most mice with knockout of NPY or its receptors eat normally under basal conditions, presumably due to adaptive changes in other appetite-regulating systems; compensatory over-expression of AgRP (see below) by the ARC NPY/AgRP neurones may contribute. The orexigenic effects of NPY appear to depend on the complicated interplay between postsynaptic Y1, Y4 and Y5 receptors (all of which stimulate eating under various conditions) and presynaptic Y2 receptors. Transgenic deletion of Y1 receptors, or the administration of Y1 receptor antagonists, reduces NPY- and fasting-induced eating (Ishigaki et al., 2005;

<option value= megaWidget < php setSelected( favoriteWidget , megaWidget ) >>The MegaWidget</option> <option value= wonderWidget < php setSelected( favoriteWidget , wonderWidget ) >>The WonderWidget</option> </select> <label for= newsletter >Do you want to receive our newsletter </label> <input type= checkbox name= newsletter id= newsletter value= yes < php setChecked( newsletter , yes ) > /> <label for= comments >Any comments </label> <textarea name= comments id= comments rows= 4 cols= 50 >< php setValue( comments ) ></textarea> <div style= clear: both; > <input type= submit name= submitButton id= submitButton value= Send Details /> <input type= reset name= resetButton id= resetButton value= Reset Form style= margin-right: 20px; /> </div> </div> </form> < php } function displayThanks() { > <h1>Thank You</h1> <p>Thank you, your application has been received.</p> < php } > </body> </html>

The first application file you re going to create is a very simple one. It contains a list of constants that configure the application. Save the following code as config.php. You might want to create a new folder in your document root called book_club, and save the file in there. You re going to create quite a few files for this application, and they ll be easier to find if they re all in one folder.

An initial achromatic response is computed by weighted summation of the nonlinear adapted cone responses modi ed with the brightness induction factor as illustrated in Equation 16.23. A similar quantity must also be computed for the white in order to facilitate computation of lightness and brightness. A = [2R + G + (1/20)B 0.305]Nbb a a a (16.23)